*For medical professionals for reference
Knowing the gout, cure "crazy"!
Written article 丨 Nanda President Endocrine Kono Zhao Xiaoqing
Gourmet, a kind of purine metabolism disorders and (or or (or or (or or (or or or (or or or (or or (or or or) Heterogeneous metabolic disease caused by uric acid excretion disorders, clinically, is characterized by hyperuricemia, gout sexual acute , goutite, intermediary nephritis, and severe cases.Deformation and dysfunction.Most of the early onset of the acute hair of gouty arthritis is the main disease. Some people describe gout to make you "crazy".
Gout can occur at any age, the most common in 40-50 years old, most of which are men.However, the changes in modern lifestyle have increased the incidence of hyperurial hemosia and gout, especially among women and young people, as well as some basic diseases such as obesity, hereditary diseases and long -term alcoholicism, and high purine diet habits.It is more likely to get sick.In order to avoid the patients pain "crazy", you must correctly understand the gout, and mainly understand the following aspects:
I. The pathological mechanism
The fundamental reason for gout is increased, resulting in the crystallization of uric acid in the joint cavity.Causes inflammation reactions (therefore, the disease is also called "metabolic arthritis").After the uric acid is elevated, gout will not be directly formed. There is a transitional stage between the two -hyperuricemia.
The source of purine in the human body is divided into endogenous and exogenous.80%.The latter mainly comes from diet, such as meat, animal viscera, seafood and alcohol.Purine is in the body to generate uric acid by dewraditors and oxidation.The human body generates about 750 mg of uric acid in one day, about 70%of uric acid is discharged by the kidneys in the form of urine, and about 30%is discharged from sweat or intestine.Therefore, the concentration of uric acid in the human body is always maintained in a dynamic balance.
When the purine metabolism disorders or uric acid excretion disorder, it can cause hyperuricemia.Excess uric acid is deposited in joints and soft tissues in the form of uric acid crystals.A large accumulation of uric acid accumulation for a long time to form gout stones.Gout is the specific manifestation of gout (the symptoms unique to the disease). It is common in the first toe, knees, ankle joints, etc. In severe cases, it will affect joints such as shoulders, hip, sacroiliac, and mandibular jaws, causing tissue foreign body inflammatory responseIn the end, it leads to gout.
2. The cause of gout
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"Congenital" factors are more critical
Gout is a inherited metabolic disease.There is no direct relationship with high purine food.In the process of synthesis and metabolism, purine is involved in multiple enzymes. The congenital abnormalities of certain enzymes will cause purine metabolism disorders, dynamic balance in the body in the body is broken, resulting in increased or decreased uric acid synthesis, and eventually triggers hyperuricemia.Essence
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"The day after tomorrow" has an impact
P ID = "35fol1g3"> It should be noted that exogenous purine accounts for only 20%of the total amount of purine.Therefore, normal people who have metabolic puppets are often not induced by gout.But for patients with gout or hyperuricemia, high purine foods may induce acute gout.This is like the relationship between sugar and diabetes: the intake of sugar in normal people does not directly lead to diabetes, but long -term high sugar diet and lack of sports will increase the risk of type 2 diabetes.Once there is diabetes, patients need to control sugar intake.In the same way, patients with gout and hyperuricemia should also strictly control high purine foods to reduce the burden on the body and reduce gout risk.Daily diet of gout patients How to eat?Three tablets are done ↓↓↓ (scan code view)
Three, relief strategies of gout symptoms
Gout can be divided into three stages, namely no symptoms, acute arthritis periods, and chronic gouting arthritis periods.Among them, the asymptomatic period is manifested as the persistent or volatility of blood uric acid, but the clinical symptoms of gout have not yet occurred.From the rise of uric acid to the occurrence of gout symptoms, time can be up to several years to decades.So, what are the asymptomatic gout patients to extend the asymptomatic period, and even let themselves do not have relevant symptoms for life?
1. Low purine diet: Patients with gout or hyperuricemia should actively understand the purine content of common foods in daily diet, and consume less high high.Purine food, adheres to low purine diet to reduce the onset of gout.According to the level of purine content, food can be divided into high, medium and low purine foods. The specific classifications are as follows:
(1) High purine food: purine content is greater than 150 mg/100 grams of 100 gramsIt mainly includes mushrooms, Hericium mushrooms, laver and other fungus algae foods, some aquatic products such as fish, catfish, sardines and other aquatic products, soup soup, fish soup, hot pot soup and other soup foods, as well as animal organs.(2) Purine food: The purine content is between 30 and 150 mg/100 grams, mainly including dark green vegetables such as poultry and animal meat, soy products, spinach, asparagus, etc.
(3) Low purine food: purine content is less than 30 mg/100 grams, mainly including milk, eggs, cabbage and other light -colored vegetables, potatoes, sweet potatoes and other rhizome vegetables, Xiaomi, oats and other miscellaneous grains, apples, strawberries and other fruits.
2. Drink more water and drink less high -sugar drinks: Studies show that drinking plenty of water can increase the speed of uric acid excretion, thereby reducing the concentration of uric acid in the body.It is recommended that the daily drinking water should be above 2000 ml, and the intake of fresh vegetables and fruits should be increased.In addition, studies have found that high sugar can promote the synthesis of uric acid and inhibit the excretion of uric acid.Therefore, patients with gout and hyperuricemia should reduce the intake of high -sugar beverages and desserts.
3. Quit alcohol: Alcohol can interfereEssenceTherefore, patients with gout and hyperuricemia must limit alcohol, especially beer intake in daily life.
4. Decrease weight and maintain a healthy lifestyle: patients with gout, hyperuricemia should maintain healthy weight and waist circumference, increase medium -intensity sports sportsExercise, but you must not exercise vigorously.Because the exercise process will consume ATP (adenine nucleoside trimer phosphate) in the body, and further produce purine, thereby increasing the uric acid level of the body.Evil sports will also increase lactic acid production, affecting the excretion of uric acid from the kidneys.Patients with obese gout can reduce uric acid through weight loss, because weight loss can reduce body volume and reduce uric acid production.At the same time, weight loss can also improve insulin resistance, further reduce uric acid synthesis and increase uric acid excretion.
5. Drug treatment: If the effect of diet control and life management is not satisfactory, you need to go to a regular hospitalAfter examinations such as X -ray, urinary ultrasound, etc., choose the appropriate uric acid reduction and symptomatic drugs according to the specific condition.
Review expert
Li Jia
Director of the Department of Endocrinology, Medical Doctor, Graduate Tutor
P>Member of the Chinese Physician Association Endocrine Metabolism Medicine Branch
Standing Committee member of the Guangdong Medical Association Endocrinology Association
Chairman of the Board Loose Prevention and Rehabilitation Committee of the Guangdong Provincial Elderly Health Association
SCI, core journals have published more than 50 papers
Ministry
In recent years, 8 authorized patents of national and provincial and ministerial funds have been presided over.
Has the conference to translate the conference
Multi -Sci Magazine reviewer
Reference Source:
[1] Nianan. Stay away from purine objects away from gout bitterness [J]. Chinese food industry, 2022, (06): 94.
[2] Li Xiang.In the Institute of Health, Institute of Food and Nutrition Development of the Ministry of Agriculture and Rural Affairs. Nutrition research and clinical practice -the 14th National Nutrition Science Conference and the 11th Asia -Pacific Clinical Nutrition Conference, the 2nd Global Chinese Nutrition Scientist Conference Abstract. The Peoples Liberation Army 65316 Hospital;, 2019: 1. Doi: 10.26914/c.cnkihy.2019.010271.
[3] The relationship between Wang Aibo.] // Institute of Education and Science, China Institute of Management Sciences. In the 2018 Teacher Education Capability Construction Research Symposium, the paper set. Fushun Haogong Aiu Niu Mining Co., Ltd.2018.005543.
This article review 丨 Li Jia, director of the Department of Endocrinology, General Hospital of the Southern Theater General Hospital, Editor -in35Fol1ik ">*" Medical "strives to publish the content of the content and reliability of the content, but do not promise the accuracy of the content; please check or use it as a basis for decision -making.
